Potential of Active Compounds in Leaves, Seeds, and Peel of Avocado Fruit (Persea americana Mill.) as In Silico Tyrosinase Enzyme Inhibitors

Melanocytes are an important component of skin pigmentation through their ability to produce melanin assisted by the enzyme tyrosinase which is a core in melanogenesis. The high phenolic and flavonoid compounds leaves, seeds avocados have potential as ligands (inhibitors) related protein-1. This study aims determine active from seeds, that play role inhibiting activity humans so it can inhibit formation melanin. research was conducted molecular anchoring method using YASARA Structure software. results showed 68 avocado skins, there were 11 had binding affinity for protein-1, namely quarcetin, epicatechin, apigenin, 3-Hydroxytyrosol, scopoletin, abscisic acid, citric coumaric acid. , quinic vanillin, caffeic compound acid ligand with best inhibitory bond free energy (∆G) -2,645 kcal/mol interacts 17 amino residues. be used reference vitro vivo studies human enzyme.